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This can lead to drug or metabolite accumulation due to reduced hepatic function, altered enzyme activity, and impaired bile flow, thereby increasing the risk of DILI [85]

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The strategy was designed to exploit methodological complementarity and reduce model-specific bias through consensus-driven prioritization across multiple screening routes

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In both conformations, E220 is engaged in an ionic interaction with R169 (TM3) that, in turn, coordinates D165 (TM2)

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