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Circulating levels decline with age, from roughly 200 ng/mL at age 20 to about 80 ng/mL by 60. Small split-face human dermatology studies, usually with fewer than 50 participants per arm, report changes in wrinkle depth and skin density

Int J Obes (Lond) 40(8):13101319 Malhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A et al (2024) Tirzepatide for the treatment of obstructive sleep apnea and obesity