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Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis
Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion
Injectable L-carnitine (IM, 500mg-1g) bypasses both the oral bioavailability problem and the GI issues GLP-1 users already experience oral L-carnitine has only ~14% absorption, and gut bacteria convert the unabsorbed remainder to TMAO (trimethylamine N-oxide), a cardiovascular risk biomarker
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