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This regulatory pattern is similar to what has been observed with xCT, as previous studies have reported that xCT expression can be induced by inflammatory stimuli, including substances like LPS and TNF

Moreover, arsenic trioxide, nitrosourea, e.g., busulfan or carmustine, or natural compounds, such as curcumine(-derivates) or piperlongumine, are potent inhibitors of the Trx and Grx systems via inhibition of TrxR, GR, or depletion of GSH [207,208] and inducers of ferroptosis [208-211]

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To study the distribution of LSC-Exo, the collected organs were fixed in 4% PFA and dehydrated with 30% sucrose solution, and then frozen in O.C.T (Tissue-Tek) and cryosectioned (5 m)