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Data availability The data generated in this study are publicly available in Gene Expression Omnibus (GEO) (RRID: SCR_005012)
Acetyl-l-carnitine is a first-in-class epigenetic regulator of genes involved in analgesic action such as the metabotropic glutamate 2 [mGlu2] receptor gene, neurotrophic factors, and antioxidant enzymes (e.g., superoxide dismutase) (Fig
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