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The underlying mechanism for this phenomenon is presumably the persistent dysregulation of energy homeostasis caused by MC4R deficiency, which cannot be fully reversed by bariatric surgery alone, leading to excessive food intake and subsequent weight regain over time
The potential interaction between TRPV1 and GLP-1-derived peptides has been elucidated through structural models
GLP-1 receptor agonists have been shown to lower blood pressure, particularly systolic blood pressure, contributing to cardiovascular health
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