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2020;32:437446.e5

Lancet 383(9911):3139 Tabernero J et al (2015) Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study

The lack of substantial overlap between these two predominant clusters suggests that the WD/LD-T group has a distinct pattern of ASV relative abundances in its microbiome compared to the other treatment groups

meanwhile, a significant increase in anti-inflammatory cytokine levels (e.g., sIL-2R) was observed in some patients (181, 184), a finding suggesting that antipsychotic drugs may exert anti-inflammatory-like effects