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In summary, these findings collectively suggest that inhibition of NF-B activation results in increased ROS production, likely mediated through the involvement of EAAT3

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Considering the control incubations: only carbon-1 of glucose gives rise to carbon dioxide, and the radioactivity in (lactate + pyruvate) is lower from [14C-1]glucose than the other positional isomers

2 Mechanisms of redox regulation in the CNS 2.1 GSH as an antioxidant in the brain The brain, being one of the most metabolically active organs in the body, requires a large share of oxygen relative to its mass